Core Competencies & Methodology Types

• Low-temperature Organolithium metalations
• Pd-catalyzed cross coupling
• Suzuki Coupling
• Stille Coupling
• Heterocyclic ring formation
• C-N, C-O, C-S Coupling
• Fluorine Chemistry
• Cycloadditions
• Condensation
• Bielectrophiles
• Binucleophiles
• Functional group elaboration

Technologies - Examples:

DMG Synthetic Routes

Our extensive experience in directed metallation chemistry enables us to synthesize complex boronic acids in the presence of sensitive functional groups

Metal-halogen exchange routes

Classical metal-halogen exchange allows rapid and reliable access to a large number of boronic acids

Pd-catalyzed routes

• Pd catalyzed coupling of organohalides with bis(pinacolato)diboron provides access to boronic esters in the presence of sensitive functional groups without Li -metal exchange
• In many cases the pinacol ester is stable where the boronic acid is not

Organostannanes

Many good positions on heterocyclic rings are not accessible via boronic acids due to their sensitivity to protodeboronation. Even stable heterocyclic boronics often suffer from protodeboronation under Suzuki conditions.

Organostannanes:

• Very general and well-established coupling conditions
• Most general C-C coupling for Combichem
• Organostannanes are best suited for heterocyclic coupling partners
• Numerous synthetic pathways for Stannanes

Multiple - versatile synthetic Routes
Organolithium chemistry allows access to a wide range of organstannanes